functional

Conformational buffering underlies functional selection in intrinsically disordered protein regions – Nature Structural & Molecular Biology

Wright, P. E. & Dyson, H. J. Intrinsically unstructured proteins: re-assessing the protein structure-function paradigm. J. Mol. Biol. 293, 321–331 (1999). CAS  PubMed  Article  Google Scholar  van der Lee, R. et al. Classification of intrinsically disordered regions and proteins. Chem. Rev. 114, 6589–6631 (2014). PubMed  PubMed Central  Article  CAS  Google Scholar  Tompa, P., Davey, N. …

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Clinical Prediction Score & Diagnosis of Acute Pancreatitis | OAEM

Functional connectivity disturbances of the locus coeruleus | NSS

Introduction Chronic insomnia disorder (CID) is an independent psychiatric syndrome that involves difficulties in falling or staying asleep that last for at least three months.1,2 CID affects an estimated 5.8 – 20.0% of the population.3 Persistent insomnia symptoms not only reduce the quality of daily life and affect work efficiency but also lead to depression, …

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Evaluation of transplacental transfer of mRNA vaccine products and functional antibodies during pregnancy and infancy – Nature Communications

Cohort We evaluated 20 pregnant individuals who received COVID-19 mRNA vaccines during pregnancy and their infants. Participants were vaccinated between December 2020 and April 2021. Gestational age at first dose ranged from 13 weeks to 40 weeks (mean 31.2, SD 5.9 weeks). Nineteen participants delivered live, singleton infants between January 2021 through April 2021 at …

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